托珠单抗-话题@MedSci

#托珠单抗#

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encodeId=eb1b11804e83e, content=<a href='/topic/show?id=e0d7546812c' target=_blank style='color:#2F92EE;'>#托珠单抗#</a>可以调节<a href='/topic/show?id=7face61750b' target=_blank style='color:#2F92EE;'>#类风湿性关节炎#</a>，这应该是确定性的, objectTitle=Clin Exp Rheumatol：托珠单抗可以调节类风湿性关节炎患者的血清脂联素和趋化素水平, objectType=article, longId=149527, objectId=b62b14952e65, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/webeditor/uploadfile/201809/20180924153132499.jpg, objectUrl=/article/show_article.do?id=b62b14952e65, replyNumber=1, likeNumber=322, createdTime=2022-01-04, rootId=0, userName=病毒猎手, userId=a33789389, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=b62b14952e65, moduleTitle=Clin Exp Rheumatol：托珠单抗可以调节类风湿性关节炎患者的血清脂联素和趋化素水平, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=b62b14952e65)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=904819, encodeId=d58890481940, content=<a href='/topic/show?id=e0d7546812c' target=_blank style='color:#2F92EE;'>#托珠单抗#</a>治疗<a href='/topic/show?id=f52851329b' target=_blank style='color:#2F92EE;'>#Covid-19#</a>，但此前已有研究否定了它有效哦, objectTitle=J Transl Med：托珠单抗治疗COVID-19的有效性和安全性分析, objectType=article, longId=204117, objectId=3f3320411ede, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/15472823_s.jpg, objectUrl=/article/show_article.do?id=3f3320411ede, replyNumber=1, likeNumber=574, createdTime=2020-12-04, rootId=0, userName=lifefamily, userId=a33789389, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=3f3320411ede, moduleTitle=J Transl Med：托珠单抗治疗COVID-19的有效性和安全性分析, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=3f3320411ede)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=813406, encodeId=e21f81340610, content=重症<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>患者使用<a href='/topic/show?id=62ca1589862' target=_blank style='color:#2F92EE;'>#Sarilumab#</a>治疗的总体临床改善率和死亡率与标准治疗没有显著差异，这也可以推导出来<a href='/topic/show?id=e0d7546812c' target=_blank style='color:#2F92EE;'>#托珠单抗#</a>（也是一种IL-6拮抗剂），应该也不会有什么作用的。<a href='/topic/show?id=94111038205a' target=_blank style='color:#2F92EE;'>#炎症因子风暴#</a>的机制比较复杂，IL-6只是其中之一。, objectTitle=Ann Rheum Dis：重症新冠肺炎炎症风暴使用sarilumab阻断白介素-6的疗效, objectType=article, longId=197867, objectId=26d719e867cc, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/2020721/1595300145989_1613704.jpg, objectUrl=/article/show_article.do?id=26d719e867cc, replyNumber=1, likeNumber=770, createdTime=2020-08-26, rootId=0, userName=lovetcm, userId=7a3710, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=26d719e867cc, moduleTitle=Ann Rheum Dis：重症新冠肺炎炎症风暴使用sarilumab阻断白介素-6的疗效, moduleType=article, 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objectCover=https://img.medsci.cn/images/20240123/ba0db996ff97459fa2ad1d9e029c3255.jpg, objectUrl=/article/show_article.do?id=74178112650a, replyNumber=0, likeNumber=98, createdTime=2024-01-27, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=加利福尼亚, moduleDTOList=[ModuleDTO(moduleId=74178112650a, moduleTitle=Lancet Rheumatol：托珠单抗生物类似药 BAT1806/BIIB800 对甲氨蝶呤反应不足的中重度类风湿性关节炎患者安全有效, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=74178112650a)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2182507, encodeId=9eca218250e12, content=<a href='/topic/show?id=6d00e616523' target=_blank style='color:#2F92EE;'>#类风湿关节炎#</a> <a href='/topic/show?id=674769813be' target=_blank style='color:#2F92EE;'>#甲氨蝶呤#</a> <a href='/topic/show?id=e0d7546812c' target=_blank style='color:#2F92EE;'>#托珠单抗#</a>, objectTitle=长期受类风湿关节炎折磨？《柳叶刀》子刊：新疗法助力患者病情缓解，惠及更多人群, 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target=_blank style='color:#2F92EE;'>#中性粒细胞#</a>存在促炎分化，并通过不断自我趋化在心脏中大量聚集。分化后的中性粒细胞直接诱导了心肌细胞表型转变并放大<a href='/topic/show?id=a6e46e060bb' target=_blank style='color:#2F92EE;'>#炎症风暴#</a>，引起心功能的快速恶化。靶向中性粒细胞自我趋化轴有望成为补充现有暴发性心肌炎治疗的新策略。象<a href='/topic/show?id=e0d7546812c' target=_blank style='color:#2F92EE;'>#托珠单抗#</a>这一类是否有效？, objectTitle=Cell Discovery：同济医院汪道文教授团队揭示暴发性心肌炎出现快速心功能下降的机制, objectType=article, longId=796050, objectId=4bb3e960508a, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20221109/1668017232524_4754896.png, objectUrl=/article/show_article.do?id=4bb3e960508a, replyNumber=0, likeNumber=128, createdTime=2023-10-14, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=4bb3e960508a, moduleTitle=Cell Discovery：同济医院汪道文教授团队揭示暴发性心肌炎出现快速心功能下降的机制, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=4bb3e960508a)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2116819, encodeId=c9012116819ad, content=这个研究对中国有现实意义，因为中国合并<a href='/topic/show?id=3d745346316' target=_blank style='color:#2F92EE;'>#慢性乙型肝炎#</a>的人很多。合并的<a href='/topic/show?id=f9d08524be' target=_blank style='color:#2F92EE;'>#HBV#</a>再激活率为2.0%，这个比例也不小了，值得重视。不过分析发现，<a href='/topic/show?id=820e3228e1b' target=_blank style='color:#2F92EE;'>#利妥昔单抗#</a>(RTX)、<a href='/topic/show?id=60ba9e805ae' target=_blank style='color:#2F92EE;'>#阿巴西普#</a>以及<a href='/topic/show?id=35791023eaf' target=_blank style='color:#2F92EE;'>#JAK抑制剂#</a>、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)抑制剂的<a href='/topic/show?id=fdd01053199b' target=_blank style='color:#2F92EE;'>#HBV再激活率#</a>为9.0%，6.0% ，1.0%，0.0%，0.0%。总体而言，JAK抑制剂是安全的，当然<a href='/topic/show?id=e0d7546812c' target=_blank style='color:#2F92EE;'>#托珠单抗#</a>等更安全, objectTitle=Immun Inflamm Dis：生物制剂或JAK抑制剂治疗类风湿性关节炎后HBsAg -/ HBcAb+患者乙型肝炎再激活的风险, objectType=article, longId=761107, objectId=9106e611071d, 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style='color:#2F92EE;'>#脂多糖#</a>，更是特别危险！从各种主要治疗来看，尤其是对ICU病人而言，大白肺主要是肺部感染和炎症，<a href='/topic/show?id=9e4210510537' target=_blank style='color:#2F92EE;'>#IL-6拮抗剂#</a><a href='/topic/show?id=e0d7546812c' target=_blank style='color:#2F92EE;'>#托珠单抗#</a>是首选，然后根据感染情况，选择合适的<a href='/topic/show?id=f5f955419b0' target=_blank style='color:#2F92EE;'>#抗生素#</a>治疗，对于重症病人，<a href='/topic/show?id=2b00554848e' target=_blank style='color:#2F92EE;'>#抗病毒药物#</a>已经没有实际意义了。当然，适当的<a href='/topic/show?id=5b0155e5081' target=_blank style='color:#2F92EE;'>#抗血小板治疗#</a>，以及<a href='/topic/show?id=ceade21712a' target=_blank style='color:#2F92EE;'>#皮质类固醇激素#</a>，如<a href='/topic/show?id=a04e4135027' target=_blank style='color:#2F92EE;'>#地塞米松#</a>，根据需要进行选择，也能抑制炎症的发展。, objectTitle=JAMA：ICU中新冠病毒感染重症病人各种治疗方案的长期结局比较, objectType=article, longId=754738, objectId=c068e54738f8, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20230104/1672878432401_4754896.jpeg, objectUrl=/article/show_article.do?id=c068e54738f8, 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hrefUrl=https://www.medsci.cn/article/show_article.do?id=cb3c20240697)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

托珠单抗

2020-05-29

健康达人 (审核中...)

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#托珠单抗#用于#新冠肺炎#，同一期相反两篇文章，如何解读？

NEJM：抗IL-6R抗体Tocilizumab治疗是否可改善重症新冠肺炎患者预后？

2021-02-26

病毒猎手 (审核中...)

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#托珠单抗#可以调节#类风湿性关节炎#，这应该是确定性的

Clin Exp Rheumatol：托珠单抗可以调节类风湿性关节炎患者的血清脂联素和趋化素水平

2022-01-04

lifefamily (审核中...)

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#托珠单抗#治疗#Covid-19#，但此前已有研究否定了它有效哦

J Transl Med：托珠单抗治疗COVID-19的有效性和安全性分析

2020-12-04

lovetcm (审核中...)

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重症#新冠肺炎#患者使用#Sarilumab#治疗的总体临床改善率和死亡率与标准治疗没有显著差异，这也可以推导出来#托珠单抗#（也是一种IL-6拮抗剂），应该也不会有什么作用的。#炎症因子风暴#的机制比较复杂，IL-6只是其中之一。

Ann Rheum Dis：重症新冠肺炎炎症风暴使用sarilumab阻断白介素-6的疗效

2020-08-26

梅斯管理员 (审核中...)

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#托珠单抗# #CAR-T# #低纤维蛋白原血症#

CAR-T后的CRS，托珠单抗治疗可导致低纤维蛋白原血症

2024-10-03发表于陕西省

梅斯管理员 (审核中...)

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#多发性骨髓瘤# #糖皮质激素# #托珠单抗# #CAR-T细胞治疗#

【BCJ】多发性骨髓瘤CAR-T治疗后使用糖皮质激素和托珠单抗不影响预后

2024-06-26发表于上海

梅斯管理员 (审核中...)

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#托珠单抗# #类风湿性关节炎（RA）#

Clin Rheumatol：托珠单抗在类风湿关节炎治疗中的持续性与效果

2024-04-18发表于上海

梅斯管理员 (审核中...)

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#托珠单抗# #CAR-T# #急性B淋巴细胞白血病#

【Cancer】托珠单抗对CD19 CAR-T治疗B-ALL的影响：中国多中心回顾性研究

2024-04-11发表于陕西省

梅斯管理员 (审核中...)

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#类风湿关节炎# #甲氨蝶呤# #托珠单抗# #生物类似药# #曾小峰#

Lancet Rheumatol：托珠单抗生物类似药 BAT1806/BIIB800 对甲氨蝶呤反应不足的中重度类风湿性关节炎患者安全有效

2024-01-27发表于加利福尼亚

梅斯管理员 (审核中...)