p53-话题@MedSci

#p53#

137篇内容 | 4818人围观

关注话题

话题活跃用户

#插入话题

插入图片

最新最热

[GetTopicListResponse(id=2241352, encodeId=b759224135221, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> <a href='/topic/show?id=8cdb1044e953' target=_blank style='color:#2F92EE;'>#铜死亡#</a>, objectTitle=Cell子刊：复旦大学周祥等合作揭示p53促进肿瘤细胞铜死亡的现象及分子机理！, objectType=article, longId=854075, objectId=61fd8540e555, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20241206/1733480378393_8538692.jpg, objectUrl=/article/show_article.do?id=61fd8540e555, replyNumber=0, likeNumber=13, createdTime=2024-12-08, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=陕西省, moduleDTOList=[ModuleDTO(moduleId=61fd8540e555, moduleTitle=Cell子刊：复旦大学周祥等合作揭示p53促进肿瘤细胞铜死亡的现象及分子机理！, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=61fd8540e555)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2239542, encodeId=4ffd22395429f, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> 在癌症治疗领域，p53基因的突变是最常见的基因突变之一，其中R175H是p53最常见的错义突变。尽管针对突变型p53的治疗方法已经有所发展，但目前尚无针对突变型p53的有效药物批准上市。美国贝勒医学院的Yong Li/Dafei Chai教授团队在本刊发表了题为“DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice”的研究论文，聚焦于开发一种能够特异性识别p53-R175H突变表位的单克隆抗体（mAb），并探索其在体外和小鼠模型中的抗肿瘤活性。, objectTitle=p53, objectType=topic, longId=13627, objectId=null, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=null, replyNumber=0, likeNumber=10, createdTime=2024-11-27, rootId=0, userName=yangchou, userId=88b489038, projectId=1, avatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, status=1, hasArticle=0, attachment=null, ipAttribution=浙江省, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2239525, encodeId=c5732239525d1, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a> <a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=论文解读| Yong Li/Dafei Chai教授团队揭示DNA递送单克隆抗体靶向p53 R175H抑制肿瘤发展的新策略, objectType=article, longId=852981, objectId=ff6f852981d0, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20241121/1732153033154_8538692.jpg, objectUrl=/article/show_article.do?id=ff6f852981d0, replyNumber=0, likeNumber=23, createdTime=2024-11-27, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=ff6f852981d0, moduleTitle=论文解读| Yong Li/Dafei Chai教授团队揭示DNA递送单克隆抗体靶向p53 R175H抑制肿瘤发展的新策略, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=ff6f852981d0)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2227774, encodeId=98ee222e7749b, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> <a href='/topic/show?id=026382811f6' target=_blank style='color:#2F92EE;'>#肿瘤免疫微环境#</a>, objectTitle=Cell子刊：靶向p53突变新机制！中国科学技术大学魏海明团队揭示了p53调节肿瘤免疫微环境的潜在机制！, objectType=article, longId=844719, objectId=57b6844e194b, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20240925/1727246740477_8538692.png, objectUrl=/article/show_article.do?id=57b6844e194b, replyNumber=0, likeNumber=47, createdTime=2024-09-26, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=57b6844e194b, moduleTitle=Cell子刊：靶向p53突变新机制！中国科学技术大学魏海明团队揭示了p53调节肿瘤免疫微环境的潜在机制！, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=57b6844e194b)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2227086, encodeId=d86f222e08662, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> <a href='/topic/show?id=01858406438' target=_blank style='color:#2F92EE;'>#胶质母细胞瘤#</a> <a href='/topic/show?id=b49013635c2' target=_blank style='color:#2F92EE;'>#p63#</a> <a href='/topic/show?id=115011939135' target=_blank style='color:#2F92EE;'>#p73#</a>, objectTitle=Commun Chem：新研究揭示突变的p53 蛋白促进p63和p73转化为癌症促进因子机制, objectType=article, longId=844240, objectId=048d84424000, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/bioon-com/20240922/1726961164412_2185383.png, objectUrl=/article/show_article.do?id=048d84424000, replyNumber=0, likeNumber=30, createdTime=2024-09-22, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=0, avatar=, status=0, hasArticle=1, attachment=null, ipAttribution=安徽省, moduleDTOList=null, followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2215705, encodeId=67812215e05cb, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> <a href='/topic/show?id=0e021801ee9' target=_blank style='color:#2F92EE;'>#T细胞受体#</a> <a href='/topic/show?id=7f1112414da' target=_blank style='color:#2F92EE;'>#MYD88#</a>, objectTitle=Science子刊：通过将CAR和TCR的优势相结合，Co-STAR T 细胞有望高效地治疗癌症, objectType=article, longId=835230, objectId=ff3f83523040, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/bioon-com/20240719/1721345193550_2185383.png, objectUrl=/article/show_article.do?id=ff3f83523040, replyNumber=0, likeNumber=78, createdTime=2024-07-19, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=0, avatar=, status=0, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=null, followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2210266, encodeId=9de022102663e, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> <a href='/topic/show?id=73216852458' target=_blank style='color:#2F92EE;'>#环磷酰胺#</a> <a href='/topic/show?id=8d82e952353' target=_blank style='color:#2F92EE;'>#网络药理学#</a> <a href='/topic/show?id=a56b1155967e' target=_blank style='color:#2F92EE;'>#化疗性脱发#</a> <a href='/topic/show?id=d81f11559ed9' target=_blank style='color:#2F92EE;'>#墨旱莲#</a>, objectTitle=J Ethnopharmacol：靶向p53/Fas通路的墨旱莲醚提取物治疗化疗性脱发的发现, objectType=article, longId=830444, objectId=d22483044486, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20240616/1718526190459_5610093.jpg, objectUrl=/article/show_article.do?id=d22483044486, replyNumber=0, likeNumber=136, createdTime=2024-06-17, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=d22483044486, moduleTitle=J Ethnopharmacol：靶向p53/Fas通路的墨旱莲醚提取物治疗化疗性脱发的发现, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=d22483044486)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2206457, encodeId=6f44220645ef4, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> <a href='/topic/show?id=adf23354483' target=_blank style='color:#2F92EE;'>#化疗#</a> <a href='/topic/show?id=e14f114834b7' target=_blank style='color:#2F92EE;'>#Schlafen11#</a>, objectTitle=改写细胞死亡法则？Science：发现癌细胞死亡的新途径——SLafen1基因, objectType=article, longId=827216, objectId=00e782e21649, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/bioon-com/20240523/1716465955919_2185383.png, objectUrl=/article/show_article.do?id=00e782e21649, replyNumber=0, likeNumber=57, createdTime=2024-05-24, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=0, avatar=, status=0, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=null, followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2200713, encodeId=a10f2200e13b6, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> <a href='/topic/show?id=502c1438175' target=_blank style='color:#2F92EE;'>#PLK1#</a> <a href='/topic/show?id=960410e97627' target=_blank style='color:#2F92EE;'>#USP28#</a> <a href='/topic/show?id=9d5f1138e3c8' target=_blank style='color:#2F92EE;'>#有丝分裂秒表复合物#</a>, objectTitle=Science：新研究揭示在细胞分裂过程中检测缺陷的分子机制, objectType=article, longId=822642, objectId=9d0982264267, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/bioon-com/20240421/1713689793276_2185383.png, objectUrl=/article/show_article.do?id=9d0982264267, replyNumber=0, likeNumber=84, createdTime=2024-04-27, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=0, avatar=, status=0, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=null, followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2181864, encodeId=968721818648c, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> <a href='/topic/show?id=16a6e66155b' target=_blank style='color:#2F92EE;'>#糖代谢#</a> <a href='/topic/show?id=f46b6403820' target=_blank style='color:#2F92EE;'>#氨基酸代谢#</a> <a href='/topic/show?id=9d0f844037d' target=_blank style='color:#2F92EE;'>#脂肪酸氧化#</a> <a href='/topic/show?id=be381101249d' target=_blank style='color:#2F92EE;'>#核苷酸代谢#</a>, objectTitle=【综述】| P53与肿瘤代谢的最新研究进展, objectType=article, longId=809507, objectId=68dd80950e27, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/conference-with-doctors-in-medical-aprons-PT29AAG.jpg, objectUrl=/article/show_article.do?id=68dd80950e27, replyNumber=0, likeNumber=124, createdTime=2024-01-15, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=陕西省, moduleDTOList=[ModuleDTO(moduleId=68dd80950e27, moduleTitle=【综述】| P53与肿瘤代谢的最新研究进展, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=68dd80950e27)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2159367, encodeId=dcb0215936e62, content=<a href='/topic/show?id=9fb41066e1c5' target=_blank style='color:#2F92EE;'>#MEG3#</a>是一种<a href='/topic/show?id=b5c936e2027' target=_blank style='color:#2F92EE;'>#印记基因#</a>，属于人类染色体14q32.3上的印记DLK1-MEG3位点。在小鼠中，它被称为基因陷阱位点 2 (Gtl2)，位于 12 号染色体的远端。 MEG3 是第一个被定义为肿瘤抑制基因的 lncRNA 基因，编码约 1.7 kb 的<a href='/topic/show?id=1da41066e2c8' target=_blank style='color:#2F92EE;'>#长非编码 RNA#</a>。在正常组织中，MEG3 在大脑和垂体中具有较高的表达水平，但垂体肿瘤和其他人类癌细胞系显示其表达缺失。 HeLa、MCF7 和 H4 癌细胞系中的异位 MEG3 表达抑制增殖。 MEG3 调节 p53 依赖性和非依赖性途径来抑制<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>生长。此外，MEG3 与 p53 启动子的结合导致 <a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a> 蛋白水平显着积累，从而诱导 p53 靶基因的表达。在<a href='/topic/show?id=d8dbe130197' target=_blank style='color:#2F92EE;'>#癌症#</a>中，MEG3 表达缺失与启动子高<a href='/topic/show?id=ec6569e7806' target=_blank style='color:#2F92EE;'>#甲基化#</a>和基因缺失相关。在<a href='/topic/show?id=0a08e451815' target=_blank style='color:#2F92EE;'>#神经胶质瘤#</a>和<a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'>#胃癌#</a>中使用去甲基化剂 5-Aza-CdR 治疗可逆转 MEG3 表达并调节 p53 水平以抑制细胞增殖。这里说能调节<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>神经元死亡（<a href='/topic/show?id=6f65e52572c' target=_blank style='color:#2F92EE;'>#程序性坏死#</a>），有点难以相信。当然，p53确实与神经元死亡有关, objectTitle=Science：长非编码RNA MEG3可能是调控阿尔茨海默病神经元死亡关键靶点，为治疗AD提供新的希望, objectType=article, longId=793164, objectId=cb95e93164a3, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20230921/68ab98968646490f99c1e321f4b9e7e7.jpg, objectUrl=/article/show_article.do?id=cb95e93164a3, replyNumber=0, likeNumber=165, createdTime=2023-09-24, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=cb95e93164a3, moduleTitle=Science：长非编码RNA MEG3可能是调控阿尔茨海默病神经元死亡关键靶点，为治疗AD提供新的希望, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=cb95e93164a3)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=1372467, encodeId=908413e246708, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=【Nature】p53缺失诱导癌症进化，或将改变肿瘤治疗格局？, objectType=article, longId=736897, objectId=624be368977b, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=624be368977b, replyNumber=0, likeNumber=139, createdTime=2022-08-26, rootId=0, userName=zhishijing, userId=5d70341, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=624be368977b, moduleTitle=【Nature】p53缺失诱导癌症进化，或将改变肿瘤治疗格局？, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=624be368977b)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1372466, encodeId=9dda13e2466b4, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=J Clin Oncol：HCT后采用Eprenetapopt+阿扎胞苷维持治疗TP53突变型AML和MDS的效益, objectType=article, longId=734319, objectId=1531e34319fe, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=1531e34319fe, replyNumber=0, likeNumber=162, createdTime=2022-08-05, rootId=0, userName=zhishijing, userId=5d70341, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=1531e34319fe, moduleTitle=J Clin Oncol：HCT后采用Eprenetapopt+阿扎胞苷维持治疗TP53突变型AML和MDS的效益, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=1531e34319fe)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1372464, encodeId=392d13e246470, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=Cancer Research：基因组守护者的叛变：最强抑癌基因p53，竟会促进肝癌发展, objectType=article, longId=732563, objectId=c502e3256314, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=c502e3256314, replyNumber=0, likeNumber=108, createdTime=2022-07-17, rootId=0, userName=zhishijing, userId=5d70341, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=c502e3256314, moduleTitle=Cancer Research：基因组守护者的叛变：最强抑癌基因p53，竟会促进肝癌发展, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=c502e3256314)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1372465, encodeId=d3f613e246589, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=癌症领域新发现！——p53和Akt途径间竟有联系？, objectType=article, longId=731902, objectId=cc4fe31902ba, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=cc4fe31902ba, replyNumber=0, likeNumber=123, createdTime=2022-07-11, rootId=0, userName=zhishijing, userId=5d70341, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=cc4fe31902ba, moduleTitle=癌症领域新发现！——p53和Akt途径间竟有联系？, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=cc4fe31902ba)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1372463, encodeId=c9a713e24639e, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=TP53突变怎么办？安罗替尼出奇制胜！, objectType=article, longId=728085, objectId=29fae28085fb, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=29fae28085fb, replyNumber=0, likeNumber=155, createdTime=2022-05-30, rootId=0, userName=zhishijing, userId=5d70341, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=29fae28085fb, moduleTitle=TP53突变怎么办？安罗替尼出奇制胜！, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=29fae28085fb)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1372462, encodeId=f7a013e24628c, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=AJH：使用基于布鲁顿酪氨酸激酶抑制剂的一线疗法治疗TP53改变的 CLL：回顾性分析, objectType=article, longId=727113, objectId=2ccae2711328, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=2ccae2711328, replyNumber=0, likeNumber=106, createdTime=2022-05-18, rootId=0, userName=zhishijing, userId=5d70341, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=2ccae2711328, moduleTitle=AJH：使用基于布鲁顿酪氨酸激酶抑制剂的一线疗法治疗TP53改变的 CLL：回顾性分析, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=2ccae2711328)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1372461, encodeId=ba2a13e24618e, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=J Thorac Oncol: TP53共突变促进EGFR突变肺腺癌的耐药进化, objectType=article, longId=301646, objectId=b80230164678, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=b80230164678, replyNumber=0, likeNumber=105, createdTime=2022-03-27, rootId=0, userName=zhishijing, userId=5d70341, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=b80230164678, moduleTitle=J Thorac Oncol: TP53共突变促进EGFR突变肺腺癌的耐药进化, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=b80230164678)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1372460, encodeId=b0b713e2460e8, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=蜘蛛丝增强p53抗癌能力，有望开发出广谱mRNA癌症疫苗, objectType=article, longId=300988, objectId=49e230098827, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=49e230098827, replyNumber=0, likeNumber=112, createdTime=2022-03-18, rootId=0, userName=zhishijing, userId=5d70341, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=49e230098827, moduleTitle=蜘蛛丝增强p53抗癌能力，有望开发出广谱mRNA癌症疫苗, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=49e230098827)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1372459, encodeId=ebe213e245971, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, objectTitle=AJH：p53 蛋白亚型的表达可预测多发性骨髓瘤患者的生存率, objectType=article, longId=300096, objectId=7a5a30009665, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=7a5a30009665, replyNumber=0, likeNumber=112, createdTime=2022-03-06, rootId=0, userName=zhishijing, userId=5d70341, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=7a5a30009665, moduleTitle=AJH：p53 蛋白亚型的表达可预测多发性骨髓瘤患者的生存率, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=7a5a30009665)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

p53

2020-05-29

梅斯管理员 (审核中...)

前往app查看评论内容

#p53# #铜死亡#

Cell子刊：复旦大学周祥等合作揭示p53促进肿瘤细胞铜死亡的现象及分子机理！

2024-12-08发表于陕西省

yangchou (审核中...)

前往app查看评论内容

全文收起 #p53# 在癌症治疗领域，p53基因的突变是最常见的基因突变之一，其中R175H是p53最常见的错义突变。尽管针对突变型p53的治疗方法已经有所发展，但目前尚无针对突变型p53的有效药物批准上市。美国贝勒医学院的Yong Li/Dafei Chai教授团队在本刊发表了题为“DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice”的研究论文，聚焦于开发一种能够特异性识别p53-R175H突变表位的单克隆抗体（mAb），并探索其在体外和小鼠模型中的抗肿瘤活性。

2024-11-27发表于浙江省

梅斯管理员 (审核中...)

前往app查看评论内容

#肿瘤# #p53#

论文解读| Yong Li/Dafei Chai教授团队揭示DNA递送单克隆抗体靶向p53 R175H抑制肿瘤发展的新策略

2024-11-27

梅斯管理员 (审核中...)

前往app查看评论内容

#p53# #肿瘤免疫微环境#

Cell子刊：靶向p53突变新机制！中国科学技术大学魏海明团队揭示了p53调节肿瘤免疫微环境的潜在机制！

2024-09-26发表于上海

梅斯管理员 (审核中...)

前往app查看评论内容

#p53# #胶质母细胞瘤# #p63# #p73#

2024-09-22发表于安徽省

梅斯管理员 (审核中...)

前往app查看评论内容

#p53# #T细胞受体# #MYD88#

2024-07-19发表于上海

梅斯管理员 (审核中...)

前往app查看评论内容

#p53# #环磷酰胺# #网络药理学# #化疗性脱发# #墨旱莲#

J Ethnopharmacol：靶向p53/Fas通路的墨旱莲醚提取物治疗化疗性脱发的发现

2024-06-17发表于上海

梅斯管理员 (审核中...)

前往app查看评论内容

#p53# #化疗# #Schlafen11#

2024-05-24发表于上海

梅斯管理员 (审核中...)

前往app查看评论内容

#p53# #PLK1# #USP28# #有丝分裂秒表复合物#

2024-04-27发表于上海

梅斯管理员 (审核中...)

前往app查看评论内容

#p53# #糖代谢# #氨基酸代谢# #脂肪酸氧化# #核苷酸代谢#

【综述】| P53与肿瘤代谢的最新研究进展

2024-01-15发表于陕西省

侠胆医心 (审核中...)