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[GetTopicListResponse(id=2233247, encodeId=6d41223324e82, content=<a href='/topic/show?id=93341286ee6' target=_blank style='color:#2F92EE;'>#NLRP3#</a> 妇科千金胶囊（FKC）是一种常用的治疗子宫内膜炎的中药，药理学研究显示其具有抗炎作用。meta分析结果证实了FKC治疗子宫内膜炎的疗效。然而，FKC预防子宫内膜炎的机制尚不清楚。既往研究证实，FKC挥发油可显著抑制NF-κB的活化，从而减少炎症因子的释放，抑制炎症反应。因此，FKC介导的炎症反应抑制可能是通过调节TLR4/NF-κB/NLRP3信号通路，抑制炎性小体介导的炎症和焦亡，预防和治疗子宫内膜炎的重要策略。, objectTitle=NLRP3, objectType=topic, longId=12867, objectId=null, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=null, replyNumber=0, likeNumber=5, createdTime=2024-10-26, rootId=0, userName=yangchou, userId=88b489038, projectId=1, avatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, status=1, hasArticle=0, attachment=null, ipAttribution=浙江省, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2233129, encodeId=9729223312939, content=<a href='/topic/show?id=4a6f1104071' 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replyNumber=0, likeNumber=125, createdTime=2018-10-29, rootId=0, userName=vera_1207, userId=981f13051678, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=1115152062dc, moduleTitle=PLos One：肺癌患者肺泡巨噬细胞中NLRP3/Caspase-1炎症小体的激活降低, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=1115152062dc)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

NLRP3

2020-05-29

yangchou (审核中...)

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全文收起 #NLRP3# 妇科千金胶囊（FKC）是一种常用的治疗子宫内膜炎的中药，药理学研究显示其具有抗炎作用。meta分析结果证实了FKC治疗子宫内膜炎的疗效。然而，FKC预防子宫内膜炎的机制尚不清楚。既往研究证实，FKC挥发油可显著抑制NF-κB的活化，从而减少炎症因子的释放，抑制炎症反应。因此，FKC介导的炎症反应抑制可能是通过调节TLR4/NF-κB/NLRP3信号通路，抑制炎性小体介导的炎症和焦亡，预防和治疗子宫内膜炎的重要策略。

2024-10-26发表于浙江省

梅斯管理员 (审核中...)

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#LPS# #NLRP3# #细胞焦亡# #子宫内膜炎# #妇科千金胶囊#

J Ethnopharmacol：妇科千金胶囊通过调节TLR4/ NF-κB /NLRP3通路抑制炎症和焦亡，减轻子宫内膜炎

2024-10-25发表于上海

梅斯管理员 (审核中...)

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#NLRP3# #肝纤维化#

论文解读｜Gopabandhu Jena教授团队揭示NLRP3炎症体在肝纤维化中的核心作用并提出治疗策略

2024-03-22发表于上海

侠胆医心 (审核中...)

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全文收起 #非酒精性脂肪肝#（NAFLD）已成为全球最常见的#慢性肝病#，其中异位脂肪变性（5%）和肝脏炎症浸润是主要临床特征。#黄芩汤#（HQD）是一种在临床上使用了数千年的#中药配方#，具有明显的#抗炎#作用。#黄芩素#、#黄芩苷#和#甘草苷#分别对蛋白#TLR4#、NF-κB和#NLRP3#表现出最高的亲和力和对接分数。

J Ethnopharmacol：黄芩汤通过抑制TLR4/NF-κB/NLRP3通路减轻高脂饮食诱导的大鼠肝脏炎症

2023-05-09发表于上海

lifestar (审核中...)

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#托法替布#通过#mTOR#/miR-223/#NLRP3#途径影响#巨噬细胞极化#抑制#结节病##肉芽肿形成#的机制研究

托法替布通过mTOR/miR-223/NLRP3途径影响巨噬细胞极化抑制结节病肉芽肿形成的机制研究

2022-11-10

vera_1207 (审核中...)

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#NLRP3#

ARD：NLRP3炎性小体激活的Tfh细胞对于高亲和力抗体的产生、生发中心形成和自身免疫至关重要

2022-07-10

vera_1207 (审核中...)

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#NLRP3#

巨噬细胞- NLRP3激活促进肺动脉高压中右心室衰竭

2022-06-17

vera_1207 (审核中...)

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#NLRP3#

J Ethnopharmacol：中药通过抑制NLRP3炎症小体对缺血性脑卒中的调控

2022-06-01

vera_1207 (审核中...)

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#NLRP3#

Front Pharmacol：疏肝和胃汤改善慢性应激模型大鼠抑郁、焦虑样行为——调节盲肠菌群和抑制NLRP3炎症小体减轻盲肠黏膜损伤

2022-04-21

vera_1207 (审核中...)

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#NLRP3#

J Inflamm Res：苏茵解毒方通过下调MAVS/NLRP3抑制焦亡和上皮-间质T转移减轻肾损伤

2021-12-20

vera_1207 (审核中...)

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#NLRP3#

AIM2和NLRP3炎症小体在辐射期间诱发IL-1介导的抗肿瘤作用

2021-12-01

vera_1207 (审核中...)

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#NLRP3#

NLRP3通过抑制cGAS-STING信号通路防治辐射诱导的结肠及皮肤损伤

2021-12-01

vera_1207 (审核中...)

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#NLRP3#

低剂量放射治疗可通过激活NLRP3炎性小体促进放射性肺炎

2021-12-01

vera_1207 (审核中...)

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#NLRP3#

NLRP3抑制剂调节免疫微环境有助于改善肺动脉高压引起的急性右心衰竭

2021-11-13

vera_1207 (审核中...)

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#NLRP3#

Front Immunol：Maf1通过抑制NF- kB/NLRP3炎症体信号通路改善败血症相关脑病的发生

2021-07-14

vera_1207 (审核中...)

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#NLRP3#

NLRP3炎症小体抑制剂Inzomelid治疗自身炎症性疾病，获得FDA授予的孤儿药称号

2020-07-17

vera_1207 (审核中...)

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#NLRP3#

Arthritis Rheumatol：直接结合NLRP3热蛋白结构域是预防NLRP3驱动炎症和痛风性关节炎的新方法

2020-03-18

vera_1207 (审核中...)

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#NLRP3#

Cell Death Dis：NEK7通过调节NLRP3炎性小体的激活调控细胞坏死和慢性结肠炎

2019-12-12

vera_1207 (审核中...)

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#NLRP3#

Circulation：NLRP3炎症小体可促进房颤的发生发展

2018-11-19

vera_1207 (审核中...)

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#NLRP3#

PLos One：肺癌患者肺泡巨噬细胞中NLRP3/Caspase-1炎症小体的激活降低

2018-10-29

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