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#代谢组学#

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target=_blank style='color:#2F92EE;'>#代谢组学#</a> <a href='/topic/show?id=0a20116550c3' target=_blank style='color:#2F92EE;'>#食物过敏（FA）#</a>, objectTitle=JACI：幼儿期代谢组学特征与食物过敏和哮喘风险, objectType=article, longId=833693, objectId=f8b283369308, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20240711/1720686441614_92910.png, objectUrl=/article/show_article.do?id=f8b283369308, replyNumber=0, likeNumber=86, createdTime=2024-07-11, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=f8b283369308, moduleTitle=JACI：幼儿期代谢组学特征与食物过敏和哮喘风险, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=f8b283369308)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2213547, encodeId=4e9b221354ef5, content=<a href='/topic/show?id=0a66254e002' target=_blank style='color:#2F92EE;'>#代谢组学#</a> 背景：炎症与疾病进展直接相关，过度炎症和不受控制的炎症级联与炎性骨关节炎、癌症、肠道疾病、动脉粥样硬化等高度相关。手术和抗炎药物是广泛使用的治疗方法，但通常只能缓解疼痛，并不是对所有患者都有效，并且由于长期使用、副作用和耐药，在目前的治疗策略中疗效有限。因此，需要一种疗效可靠、毒性低的替代药物来抑制炎症。石柑子(PCM)在中国瑶药“十八钻”之一，具有抗炎、降血糖、抗肿瘤等生理活性，常用于治疗瘀伤、风湿、麻痹等骨科疾病。既往研究中发现PCM具有显著的抗炎特性。然而，PCM抗炎作用的物质基础和潜在机制尚不清楚。目的：通过血清药物化学、网络药理学和血清代谢组学的综合研究，探讨PCM的有效成分及其抗炎作用机制。方法：分别采用UPLC- qtof -MS/MS和UPLC对PCM的化学成分进行定性和定量分析，并对PCM进入血液的原型成分进行分析。基于其被血液吸收的特征，利用网络药理学方法发现了PCM抗炎的潜在靶点和信号通路。此外，利用UPLC-QTOF-MS/MS进行代谢组学研究，确定了与PCM抗炎作用相关的生物标志物和代谢途径。最后，通过体内和体外实验验证了假设的机制。结果：首次从PCM中鉴定出40种化学成分，并对其中7种进行了定量分析，同时发现5种血清迁移原型成分。网络药理学KEGG富集分析显示花生四烯酸代谢、酪氨酸代谢、TNF信号通路、NF-κB信号通路和苯丙氨酸代谢是PCM抗炎的主要信号通路。药效学结果显示，PCM改善了肝损伤和炎症细胞浸润，下调了肝脏中IL-1β、NF-κB p65和MyD88蛋白的表达。代谢组学研究鉴定出53种不同的血清代谢物，主要与嘌呤和嘧啶代谢、苯丙氨酸代谢、原胆汁酸生物合成和甘油磷脂代谢有关。综合结果表明，PCM的抗炎调节网络与PCM的5种代谢物、3种代谢途径、7个靶点和4种活性成分有关。此外，分子对接鉴定了活性成分与核心靶点的结合能力，并通过体外实验验证了活性成分的抗炎功效。结论：该研究证实了PCM的抗炎作用，这些发现为PCM抗炎的有效成分和代谢机制提供了新的认识。原始出处： Xiao G, Yang M, Zeng Z, et al. Investigation into the anti-inflammatory mechanism of Pothos chinensis (Raf.) Merr. by regulating TLR4/MyD88/NF-κB pathway: Integrated network pharmacology, serum pharmacochemistry, and metabolomics. J Ethnopharmacol. 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代谢组学

2020-05-29发表于威斯康星

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#代谢组学# #黄葵胶囊# #中医方证代谢组学# #肾脏保护作用# #STZ诱导T1DN#

J Ethnopharmacol：通过综合血清代谢组学分析，探讨黄葵胶囊对糖尿病肾病小鼠肾保护作用的分子机制

2024-12-22发表于上海

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#糖尿病肾病# #代谢组学# #网络药理学# #大柴胡汤# #AGEs/RAGE/AKT通路#

J Ethnopharmacol：结合代谢组学和网络药理学研究大柴胡汤对糖尿病小鼠肾损伤的预防作用

2024-12-16发表于上海

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#心力衰竭# #蛋白质组学# #代谢组学# #PI3K/AKT信号通路# #健心颗粒# #丙酮酸代谢#

Chin Med：基于蛋白质组学和代谢组学研究健心颗粒治疗心力衰竭的作用机制

2024-11-30发表于上海

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#中医药# #血管生成# #代谢组学# #网络药理学# #PI3K/AKT/mTOR信号通路# #生物活性成分#

Chin Med：血瘀逐瘀汤的生物活性成分及其对创伤性脑损伤的血管生成作用

2024-09-29发表于上海

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#代谢组学# #网络药理学# #胆汁淤积性肝损伤# #血清药物化学# #茵陈四逆汤#

J Ethnopharmacol：茵陈四逆汤治疗ANIT诱导胆汁淤积性肝损伤的潜在有效成分和作用机制

2024-08-22发表于上海

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#代谢组学# #质谱成像# #脑缺血再灌注损伤# #黄芪-红花# #脑微区#

Phytomedicine：黄芪-红花对脑缺血/再灌注损伤的疗效—代谢组学和质谱成像的见解

2024-08-19发表于上海

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#心力衰竭# #代谢组学#

EBioMedicine：心力衰竭中血浆肌醇升高：临床意义和预后意义

2024-08-11发表于上海

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#非酒精性脂肪性肝病# #基因组学# #蛋白质组学# #代谢组学#

特别关注｜非酒精性脂肪性肝病多组学研究现状

2024-07-22发表于上海

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