NEUROLOGY：口腔溃疡与智商下降有关
2013-05-13 koo 生物360
日前，美国纽约哥伦比亚大学医学中心的研究人员对曼哈顿北部1600多名年龄在69岁左右的居民进行了血样检测，发现血液中存在一些病毒可能导致智力、记忆力下降。相关研究论文刊登在了近期出版的《神经学》杂志上。研究人员表示，疱疹病毒可导致嘴唇上出现小溃疡，这与其它类似感染一样，可能与智力问题有关。若在人的血液中发现大量抗体则表明人体被感染，即有可能患某种疾病。拿疱疹病毒来说，若血液中一类疱疹病毒数量较多，
日前，美国纽约哥伦比亚大学医学中心的研究人员对曼哈顿北部1600多名年龄在69岁左右的居民进行了血样检测，发现血液中存在一些病毒可能导致智力、记忆力下降。相关研究论文刊登在了近期出版的《神经学》杂志上。
研究人员表示，疱疹病毒可导致嘴唇上出现小溃疡，这与其它类似感染一样，可能与智力问题有关。
若在人的血液中发现大量抗体则表明人体被感染，即有可能患某种疾病。拿疱疹病毒来说，若血液中一类疱疹病毒数量较多，则易患认知性困难疾病。疱疹病毒和认知困难之间的联系在女性中更为明显，尤其是受教育度不高，没有医保，不经常用脑的女性。
虽然还需要进一步的调查，但现在的结果已可帮助我们及时发现这种疾病，并降低患病风险。例如，我们可以通过加强记忆力训练，给孩子及时接种疫苗等办法来降低其出现几率。
与智商相关的拓展阅读：
Objective
We hypothesized that infectious burden (IB), a composite serologic measure of exposure to common pathogens (i.e., Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus 1 and 2) associated with vascular risk in the prospective Northern Manhattan Study (NOMAS), would also be associated with cognition.
Methods
Cognition was assessed using the Mini-Mental State Examination (MMSE) at enrollment and the modified Telephone Interview for Cognitive Status (TICS-m) at annual follow-up visits. Adjusted linear and logistic regressions were used to measure the association between IB index and MMSE. Generalized estimating equation models were used to evaluate associations with TICS-m and its change over time.
Results
Serologies and cognitive assessments were available in 1,625 participants of the NOMAS cohort. In unadjusted analyses, higher IB index was associated with worse cognition (change per standard deviation [SD] of IB for MMSE was −0.77, p < 0.0001, and for first measurements of TICS-m was −1.89, p < 0.0001). These effects were attenuated after adjusting for risk factors (for MMSE adjusted change per SD of IB = −0.17, p = 0.06, for TICS-m adjusted change per SD IB = −0.68, p < 0.0001). IB was associated with MMSE ≤24 (compared to MMSE >24, adjusted odds ratio 1.26 per SD of IB, 95% confidence interval 1.06–1.51). IB was not associated with cognitive decline over time. The results were similar when IB was limited to viral serologies only.
Conclusion
A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
作者：koo
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病毒对人体的影响还是比较大的
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#Neurol#
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#智商#
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