Nature:mTOR信号与癌症转移密切相关
2012-03-03 MedSci MedSci原创
近期来自加州大学旧金山分校的研究人员在新研究中解析了细胞内蛋白质合成的“主控因子”—— mTOR调控的基因网络,由此揭示出了这一信号异常导致癌症转移的分子机制。这一研究发现在线发表在2月22日的《自然》(Nature)杂志上。 mTOR是人类蛋白质合成的“主要调控因子”,它能够帮助正常细胞感受营养状态,调控细胞生长与代谢。但是在多种类型的癌症中,这一过程出现异常,mTOR重编程正
近期来自加州大学旧金山分校的研究人员在新研究中解析了细胞内蛋白质合成的“主控因子”—— mTOR调控的基因网络,由此揭示出了这一信号异常导致癌症转移的分子机制。这一研究发现在线发表在2月22日的《自然》(Nature)杂志上。
The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream translationally regulated nodes of gene expression that may direct cancer development are poorly characterized. Using ribosome profiling, we uncover specialized translation of the prostate cancer genome by oncogenic mTOR signalling, revealing a remarkably specific repertoire of genes involved in cell proliferation, metabolism and invasion. We extend these findings by functionally characterizing a class of translationally controlled pro-invasion messenger RNAs that we show direct prostate cancer invasion and metastasis downstream of oncogenic mTOR signalling. Furthermore, we develop a clinically relevant ATP site inhibitor of mTOR, INK128, which reprograms this gene expression signature with therapeutic benefit for prostate cancer metastasis, for which there is presently no cure. Together, these findings extend our understanding of how the ‘cancerous’ translation machinery steers specific cancer cell behaviours, including metastasis, and may be therapeutically targeted
期刊名称: nature
作者:MedSci
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